免疫原
Synthesized phosho peptide around human eIF4B (Ser406)
特异性
This antibody detects endogenous levels of Human Mouse Rat eIF4B (phospho-Ser406)
来源
Polyclonal, Rabbit,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
功能
function:Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Self-associates and interacts with EIF3 p170 subunit.,
其他名称
Eukaryotic translation initiation factor 4B (eIF-4B)
Fields
>>mTOR signaling pathway;>>PI3K-Akt signaling pathway;>>Proteoglycans in cancer
细胞定位
cytosol,polysome,eukaryotic translation initiation factor 4F complex,dendrite,neuronal cell body,
组织表达
Adipose tissue,Brain,Cervix carcinoma,Epithelium,Liver,Lung