免疫原
The antiserum was produced against synthesized peptide derived from human Arrestin 1 around the phosphorylation site of Ser412. AA range:369-418
特异性
Phospho-Arrestin-β-1 (S412) Polyclonal Antibody detects endogenous levels of Arrestin-β-1 protein only when phosphorylated at S412.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011],
功能
function:Regulates beta-adrenergic receptor function. Beta-arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins.,online information:Arrestin entry,similarity:Belongs to the arrestin family.,
其他名称
ARRB1; ARR1; Beta-arrestin-1; Arrestin beta-1
Fields
>>MAPK signaling pathway;>>Chemokine signaling pathway;>>Endocytosis;>>Hedgehog signaling pathway;>>Dopaminergic synapse;>>Olfactory transduction;>>Relaxin signaling pathway;>>Parathyroid hormone synthesis, secretion and action;>>GnRH secretion;>>Morphine addiction;>>Chemical carcinogenesis - receptor activation
细胞定位
Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit . Cell projection, pseudopodium . Cytoplasmic vesicle. Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. The monomeric form is predominantly located in the nucleus. The oligomeric form is located in the cytoplasm. Translocates to the nucleus upon stimulation of OPRD1 (By similarity). .
组织表达
Brain,Peripheral blood,Uterus,
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