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WDR79 Monoclonal Antibody

说明书

BYab-03447

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB
分子量(DA)
免疫原
Purified recombinant human WDR79 protein fragments expressed in E.coli.
特异性
WDR79 Monoclonal Antibody detects endogenous levels of WDR79 protein.
来源
Monoclonal, Mouse
组成(Formulation)
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
稀释比例
Western Blot: 1/1000 - 1/2000. Not yet tested in other applications.
纯化工艺(Immunogen)
Affinity purification
浓度
1 mg/ml
背景(Background)
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011],
功能
DNA metabolic process, telomere organization, telomere assembly, telomere formation via telomerase, positive regulation of catalytic activity, positive regulation of molecular function, chromosome organization, regulation of transferase activity, positive regulation of transferase activity, regulation of telomerase activity, positive regulation of telomerase activity,
基因名称(Gene Name)
WRAP53
蛋白名称
Telomerase Cajal body protein 1
简称
WDR79
其他名称
WRAP53; TCAB1; WDR79; Telomerase Cajal body protein 1; WD repeat-containing protein 79; WD40 repeat-containing protein encoding RNA antisense to p53
Fields
人基因ID
55135
人蛋白质序列数据库
Q9BUR4
小鼠基因ID
216853
小鼠蛋白质序列数据库
Q8VC51
大鼠基因ID
287432
大鼠蛋白质序列数据库
Q5XII5
细胞定位
Nucleus, Cajal body . Chromosome, telomere . Chromosome . Released from telomerase RNA template component (TERC) in mitotic cells coincident with delocalization from Cajal bodies (PubMed:26170453). In response to DNA damage, localizes to sites of DNA double-strand breaks following phosphorylation by ATM (PubMed:26734725, PubMed:27715493). .
组织表达
Expressed in all tissues and cell lines examined.
储存(Storage)
-20°C/1 year

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WDR79 Monoclonal Antibody

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