免疫原
The antiserum was produced against synthesized peptide derived from human Vitamin D Receptor around the phosphorylation site of Ser208. AA range:181-230
特异性
Phospho-VDR (S208) Polyclonal Antibody detects endogenous levels of VDR protein only when phosphorylated at S208.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011],
功能
caution:It is uncertain whether Met-1 or Met-4 is the initiator.,disease:Defects in VDR are the cause of type IIA rickets [MIM:277440]; also known as hypocalcemic vitamin D-resistant rickets (HVDRR). HVDRR is most frequently an autosomal recessive disorder characterized by severe rickets, hypocalcemia and secondary hyperparathyroidism.,domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,function:Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essentia
其他名称
VDR; NR1I1; Vitamin D3 receptor; VDR; 1; 25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1
Fields
>>Parathyroid hormone synthesis, secretion and action;>>Endocrine and other factor-regulated calcium reabsorption;>>Mineral absorption;>>Tuberculosis;>>Chemical carcinogenesis - receptor activation
细胞定位
Nucleus . Cytoplasm . Localizes mainly to the nucleus (PubMed:28698609, PubMed:12145331). Localization to the nucleus is enhanced by vitamin D3. .
组织表达
Lens epithelium,Peripheral blood,Placenta,Rectum,
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