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KLF4 mouse mAb

说明书

BYab-02957

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB
分子量(DA)
55/65kD
免疫原
Purified recombinant mouse KLF4 protein fragments expressed in E.coli.
特异性
Transfected Only.
来源
Monoclonal, Mouse
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
wb 1:1000
纯化工艺(Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
背景(Background)
This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015],
功能
function:Transcription factor which acts as both an activator and repressor. Binds the CACCC core sequence. Binds to multiple sites in the 5'-flanking region of its own gene and can activate its own transcription. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,subunit:Interaction with the C-terminal domain of MUC1 enhances suppression of TP53/p53 transcription.,
基因名称(Gene Name)
klf4
蛋白名称
简称
KLF4
其他名称
Endothelial Kruppel like zinc finger protein;Epithelial zinc finger protein EZF;EZF;GKLF;Gut-enriched krueppel-like factor;KLF;KLF4;KLF4_HUMAN;Krueppel-like factor 4;Kruppel like factor 4 (Epithelial zinc finger protein EZF) (Gut enriched Krueppel like factor);Kruppel like factor 4 (gut).
Fields
>>Signaling pathways regulating pluripotency of stem cells;>>Chemical carcinogenesis - receptor activation
人基因ID
16600
人蛋白质序列数据库
O43474
小鼠基因ID
小鼠蛋白质序列数据库
Q60793
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Nucleus.
组织表达
Cervix,Lung,Placenta,Substantia nigra,Tongue,
储存(Storage)
-20°C/1 year

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KLF4 mouse mAb

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