免疫原
The antiserum was produced against synthesized peptide derived from human RAP1. AA range:203-252
特异性
RAP1 Polyclonal Antibody detects endogenous levels of RAP1 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000;IHC-p 1:50-300
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22. [provided by RefSeq, Apr 2010],
功能
function:May play a role in telomere length regulation. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.,miscellaneous:Recruited to telomeres by TRF2; seemingly it does not directly bind to DNA itself.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Translated as Glu.,similarity:Contains 1 BRCT domain.,similarity:Contains 1 Myb-like domain.,subcellular location:Colocalizes with telomeric DNA in interphase and metaphase cells.,subunit:Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TE
蛋白名称
Telomeric repeat-binding factor 2-interacting protein 1
其他名称
TERF2IP; DRIP5; RAP1; PP8000; Telomeric repeat-binding factor 2-interacting protein 1; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1; Dopamine receptor-interacting protein 5; Repressor/activator protein 1 homol
细胞定位
Nucleus . Cytoplasm . Chromosome . Chromosome, telomere . Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex. .
组织表达
Ubiquitous. Highly expressed.
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