免疫原
The antiserum was produced against synthesized peptide derived from human NQO1. AA range:203-252
特异性
NQO1 Polyclonal Antibody detects endogenous levels of NQO1 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. IF 1:50-200 ELISA: 1/10000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
功能
catalytic activity:NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone.,cofactor:FAD.,enzyme regulation:Inhibited by dicoumarol.,function:The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.,induction:By dioxin.,mass spectrometry: PubMed:11735396,miscellaneous:Quinone reductase accepts electrons from both NADH and NADPH with equal efficiency.,polymorphism:The Ser-187 polymorphism may be linked to susceptibility to forms of cancers.,similarity:Belongs to the NAD(P)H dehydrogenase (quinone) family.,subunit:Homodimer.,
蛋白名称
NAD(P)H dehydrogenase [quinone] 1
其他名称
NQO1; DIA4; NMOR1; NAD(P)H dehydrogenase [quinone] 1; Azoreductase; DT-diaphorase; DTD; Menadione reductase; NAD(P)H:quinone oxidoreductase 1; Phylloquinone reductase; Quinone reductase 1; QR1
Fields
>>Ubiquinone and other terpenoid-quinone biosynthesis;>>Metabolic pathways;>>Biosynthesis of cofactors;>>Pathways in cancer;>>Chemical carcinogenesis - reactive oxygen species;>>Hepatocellular carcinoma;>>Fluid shear stress and atherosclerosis
细胞定位
Cytoplasm, cytosol .
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