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Thioredoxin Monoclonal Antibody

说明书

BYab-02340

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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产品简介>

宿主
反应性
应用
WB;ELISA
分子量(DA)
免疫原
Purified recombinant fusion protein with Thioredoxin tag.
特异性
Thioredoxin Monoclonal Antibody detects endogenous levels of Thioredoxin protein.
来源
Monoclonal, Mouse
组成(Formulation)
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺(Immunogen)
Affinity purification
浓度
背景(Background)
The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
功能
function:ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).,function:Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity.,PTM:In the fully reduced protein, both Cys-69 and Cys-73 are nitrosylated in response to nitric oxide (NO). When two disulfide bonds are present in the protein, only Cys-73 is nitrosylated. Cys-73 can serve as donor for nitrosylation of target proteins.,similarity:Belongs to the thioredoxin family.,similarity:Contains 1 thioredoxin domain.,subunit:Homodimer; di
基因名称(Gene Name)
TXN
蛋白名称
Thioredoxin
简称
Thioredoxin
其他名称
TXN; TRDX; TRX; TRX1; Thioredoxin; Trx; ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASP
Fields
>>NOD-like receptor signaling pathway;>>Parkinson disease;>>Salmonella infection;>>Fluid shear stress and atherosclerosis
人基因ID
7295
人蛋白质序列数据库
P10599
小鼠基因ID
小鼠蛋白质序列数据库
P10639
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Nucleus . Cytoplasm . Secreted . Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA) (PubMed:9108029). Predominantly in the cytoplasm in non irradiated cells (PubMed:11118054). Radiation induces translocation of TRX from the cytoplasm to the nucleus (PubMed:11118054). Secreted by a leaderless secretory pathway (PubMed:1332947). .
组织表达
Brain,Cajal-Retzius cell,Cerebellum,Cervix,Epithelium,Fetal brain cortex,Hepatocyte,Lens,Ma
储存(Storage)
-20°C/1 year

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Thioredoxin Monoclonal Antibody

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