免疫原
Synthesized peptide derived from the C-terminal region of human SNM1B.
特异性
SNM1B Polyclonal Antibody detects endogenous levels of SNM1B protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000 [PubMed 10848582]).[supplied by OMIM, Mar 2008],
功能
function:May be required for DNA interstrand cross-link repair.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.,subcellular location:Localizes to discrete foci.,
蛋白名称
5' exonuclease Apollo
其他名称
DCLRE1B; SNM1B; 5' exonuclease Apollo; DNA cross-link repair 1B protein; SNM1 homolog B; SNMIB; hSNM1B
细胞定位
Chromosome, telomere. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Mainly localizes to telomeres, recruited via its interaction with TERF2. During mitosis, localizes to the centrosome.
组织表达
Placenta,Retinoblastoma,Teratocarcinoma,
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