免疫原
The antiserum was produced against synthesized peptide derived from human RNF130. AA range:231-280
特异性
RNF130 Polyclonal Antibody detects endogenous levels of RNF130 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
ring finger protein 130(RNF130) Homo sapiens The protein encoded by this gene contains a RING finger motif and is similar to g1, a Drosophila zinc-finger protein that is expressed in mesoderm and involved in embryonic development. The expression of the mouse counterpart was found to be upregulated in myeloblastic cells following IL3 deprivation, suggesting that this gene may regulate growth factor withdrawal-induced apoptosis of myeloid precursor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
功能
function:May have a role during the programmed cell death of hematopoietic cells.,similarity:Contains 1 PA (protease associated) domain.,similarity:Contains 1 RING-type zinc finger.,
蛋白名称
E3 ubiquitin-protein ligase RNF130
其他名称
RNF130; E3 ubiquitin-protein ligase RNF130; Goliath homolog; H-Goliath; RING finger protein 130
细胞定位
Membrane ; Single-pass type I membrane protein . Cytoplasm .
组织表达
Ubiquitously expressed. Highly expressed in leukocytes. Not expressed in erythroblasts.
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