免疫原
The antiserum was produced against synthesized peptide derived from human PRP31. AA range:331-380
特异性
PRPF31 Polyclonal Antibody detects endogenous levels of PRPF31 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs.[provided by RefSeq, Jan 2009],
功能
disease:Defects in PRPF31 are the cause of retinitis pigmentosa type 11 (RP11) [MIM:600138]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP11 inheritance is autosomal dominant.,function:Involved in pre-mRNA splicing. Required for U4/U6.U5 tri-snRNP formation.,similarity:Contains 1 Nop domain.,subcellular location:Predominantly found in speckles and in Cajal bodies.,subunit:Part of a tri-snRNP complex. Interacts with C20orf14/U5 snRNP-associated 102 kDa protein.,tissue specificity:Ubiquitously expressed.,
蛋白名称
U4/U6 small nuclear ribonucleoprotein Prp31
其他名称
PRPF31; PRP31; U4/U6 small nuclear ribonucleoprotein Prp31; Pre-mRNA-processing factor 31; Serologically defined breast cancer antigen NY-BR-99; U4/U6 snRNP 61 kDa protein; Protein 61K; hPrp31
细胞定位
Nucleus . Nucleus speckle . Nucleus, Cajal body . Predominantly found in speckles and in Cajal bodies. .
组织表达
Ubiquitously expressed.
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