免疫原
The antiserum was produced against synthesized peptide derived from human LIPB1. AA range:300-349
特异性
Liprin β1 Polyclonal Antibody detects endogenous levels of Liprin β1 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000;IHC-p 1:50-300
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],
功能
domain:The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type beta/beta. The C-terminal, non-coiled coil regions mediate heterodimerization type beta/alpha and interaction with S100A4.,function:May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.,similarity:Belongs to the liprin family. Liprin-beta subfamily.,similarity:Contains 3 SAM (sterile alpha motif) domains.,subunit:Forms homodimers and heterodimers. Interacts with S100A4 in a calcium-dependent mode.,tissue specificity:Widely expressed. Absent in liver.,
其他名称
PPFIBP1; KIAA1230; Liprin-beta-1; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1; PTPRF-interacting protein-binding protein 1; hSGT2
细胞定位
plasma membrane,cell-cell adherens junction,focal adhesion,
组织表达
Widely expressed. Absent in liver.
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