免疫原
The antiserum was produced against synthesized peptide derived from human GCN5L2. AA range:691-740
特异性
GCN5 Polyclonal Antibody detects endogenous levels of GCN5 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009],
功能
somitogenesis, regionalization, chromatin organization, chromatin remodeling, transcription, transcription, DNA-dependent, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter,transcription from RNA polymerase II promoter, protein amino acid acetylation, pattern specification process,embryonic development ending in birth or egg hatching, anterior/posterior pattern formation, chromatin modification,covalent chromatin modification, histone modification, histone acetylation, histone deubiquitination, protein deubiquitination, RNA biosynthetic process, segmentation, chordate embryonic development, protein amino acid acylation, histone H3 acetylation, regulation of transcription, regulation of RNA metabolic process, chromosome organization, protein modification by small protein removal, protein modification by small protein conjugation or rem
蛋白名称
Histone acetyltransferase KAT2A
其他名称
KAT2A; GCN5; GCN5L2; HGCN5; Histone acetyltransferase KAT2A; General control of amino acid synthesis protein 5-like 2; Histone acetyltransferase GCN5; HsGCN5; Lysine acetyltransferase 2A; STAF97
Fields
>>Viral life cycle - HIV-1;>>Notch signaling pathway;>>Thyroid hormone signaling pathway;>>Human T-cell leukemia virus 1 infection;>>Viral carcinogenesis
细胞定位
Nucleus . Chromosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Mainly localizes to the nucleus (PubMed:27796307). Also localizes to centrosomes in late G1 and around the G1/S transition, coinciding with the onset of centriole formation (PubMed:27796307). .
组织表达
Expressed in all tissues tested.
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