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CRSP77 Polyclonal Antibody

说明书

BYab-01628

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB;IHC;IF;ELISA
分子量(DA)
73kD
免疫原
The antiserum was produced against synthesized peptide derived from human MED17. AA range:141-190
特异性
CRSP77 Polyclonal Antibody detects endogenous levels of CRSP77 protein.
来源
Polyclonal, Rabbit,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
背景(Background)
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008],
功能
function:Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the Mediator complex subunit 17 family.,subunit:Interacts with GATA1 and PPARG (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED2
基因名称(Gene Name)
MED17
蛋白名称
Mediator of RNA polymerase II transcription subunit 17
简称
CRSP77
其他名称
MED17; ARC77; CRSP6; DRIP77; DRIP80; TRAP80; Mediator of RNA polymerase II transcription subunit 17; Activator-recruited cofactor 77 kDa component; ARC77; Cofactor required for Sp1 transcriptional activation subunit 6; CRSP complex subunit
Fields
>>Thyroid hormone signaling pathway
人基因ID
9440
人蛋白质序列数据库
Q9NVC6
小鼠基因ID
234959
小鼠蛋白质序列数据库
Q8VCD5
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Nucleus .
组织表达
Ubiquitous.
储存(Storage)
-20°C/1 year

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CRSP77 Polyclonal Antibody

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