免疫原
Synthesized phosho peptide around human IRF-7 (Ser471 and 472)
特异性
This antibody detects endogenous levels of Human IRF-7 (phospho-Ser471 or 472) Mouse IRF-7 (phospho-Ser425 or 426), Rat IRF-7 (phospho-Ser423 or 424)
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000;IHC-p 1:50-300
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008],
功能
function:Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) in IFN promoters and in the Q promoter (Qp) of EBV nuclear antigen 1 (EBNA1). Functions as a molecular switch for antiviral activity. Activated by phosphorylation in response to infection. Activation leads to nuclear retention, DNA binding, and derepression of transactivation ability.,induction:By type I interferons.,PTM:In response to a viral infection, phosphorylated on the C-terminal serine cluster. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein E3.,similarity:Belongs to the IRF family.,similarity:Contains 1 tryptophan pentad repeat DNA-binding domain.,subcellular location:The phosphorylated and active form accumulates selectively in the nucleus.,subunit:Homodimer; phosphorylation-induced. Interacts with TICAM1 and TICAM2. Interacts with rotavirus A NSP1; t
其他名称
Interferon regulatory factor 7 (IRF-7)
Fields
>>Toll-like receptor signaling pathway;>>NOD-like receptor signaling pathway;>>RIG-I-like receptor signaling pathway;>>Cytosolic DNA-sensing pathway;>>Hepatitis C;>>Hepatitis B;>>Measles;>>Influenza A;>>Kaposi sarcoma-associated herpesvirus infection;>>Herpes simplex virus 1 infection;>>Epstein-Barr virus infection;>>Viral carcinogenesis;>>Lipid and atherosclerosis
细胞定位
Nucleus. Cytoplasm. The phosphorylated and active form accumulates selectively in the nucleus.
组织表达
Expressed predominantly in spleen, thymus and peripheral blood leukocytes.
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