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SMAD5(C-term) mouse mAb

说明书

BYab-01077

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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产品简介>

宿主
反应性
应用
WB;ICC;FC
分子量(DA)
60kD
免疫原
Purified recombinant human SMAD5 (C-terminus) protein fragments expressed in E.coli.
特异性
This antibody detects endogenous levels of SMAD5 (C-terminus) and does not cross-react with related proteins.
来源
Monoclonal, Mouse
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
wb 1:1000 icc 1:75 fcm 1:100
纯化工艺(Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
背景(Background)
The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014],
功能
function:Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).,PTM:Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.,PTM:Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.,similarity:Belongs to the dwarfin/SMAD family.,similarity:Contains 1 MH1 (MAD homology 1) domain.,similarity:Contains 1 MH2 (MAD homology 2) domain.,subcellular location:Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.,subunit:May form trimers with the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit and SMURF1. Interacts with SUV39H1 and SUV39H2.,tissue specificity:Ubiquitous.,
基因名称(Gene Name)
smad5
蛋白名称
简称
Smad5
其他名称
DKFZp781C1895;DKFZp781O1323;Dwfc;hSmad 5;hSmad5;JV5 1;JV5-1;MAD homolog 5;MAD mothers against decapentaplegic homolog 5;MAD, mothers against decapentaplegic homolog 5;MADH 5;MADH5;Mothers against decapentaplegic homolog 5;Mothers against DPP homolog 5;MusMLP; SMA and MAD related protein 5;SMAD 5;SMAD family member 5;SMAD mothers against DPP homolog 5;Smad5;Smad5;SMAD5_HUMAN.
Fields
>>TGF-beta signaling pathway;>>Signaling pathways regulating pluripotency of stem cells
人基因ID
4090
人蛋白质序列数据库
Q99717
小鼠基因ID
小鼠蛋白质序列数据库
P97454
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.
组织表达
Ubiquitous.
储存(Storage)
-20°C/1 year

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SMAD5(C-term) mouse mAb

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