hnRNP U Monoclonal Antibody

宿主

反应性

应用

WB

分子量（DA）

免疫原

Purified recombinant human hnRNP U protein fragments expressed in E.coli.

特异性

hnRNP U Monoclonal Antibody detects endogenous levels of hnRNP U protein.

来源

Monoclonal, Mouse

组成（Formulation）

Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

稀释比例

Western Blot: 1/1000 - 1/2000. Not yet tested in other applications.

纯化工艺（Immunogen）

Affinity purification

浓度

1 mg/ml

背景（Background）

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the

功能

function:Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Bind to double- and single-stranded DNA and RNA.,PTM:Arg-732 and Arg-738 are dimethylated, probably to asymmetric dimethylarginine.,PTM:Extensively phosphorylated.,similarity:Contains 1 B30.2/SPRY domain.,similarity:Contains 1 SAP domain.,subcellular location:Component of ribonucleosomes. Also found associated with the cell surface.,subunit:Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRNPA1, HNRNPA2B1, HNRPA3, HNRNPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRNPR, HNRNPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1,

基因名称（Gene Name）

HNRNPU

蛋白名称

Heterogeneous nuclear ribonucleoprotein U

简称

hnRNP U

其他名称

HNRNPU; HNRPU; SAFA; U21.1; Heterogeneous nuclear ribonucleoprotein U; hnRNP U; Scaffold attachment factor A; SAF-A; p120; pp120

Fields

>>Spliceosome

人基因ID

3192

人蛋白质序列数据库

Q00839

小鼠基因ID

小鼠蛋白质序列数据库

Q8VEK3

大鼠基因ID

大鼠蛋白质序列数据库

细胞定位

Nucleus . Nucleus matrix . Chromosome . Nucleus speckle . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, spindle pole . Midbody . Cytoplasm . Cell surface . Cytoplasmic granule . Localizes at inactive X chromosome (Xi) regions (PubMed:11003645, PubMed:14608463, PubMed:15563465). Localizes in the nucleus during interphase (PubMed:21242313). At metaphase, localizes with mitotic spindle microtubules (MTs) (PubMed:21242313). At anaphase, localizes in the mitotic spindle midzone (PubMed:21242313). Localizes in spindle MTs proximal to spindle poles in a TPX2- and AURKA-dependent manner (PubMed:21242313). The Ser-59 phosphorylated form localizes to centrosomes during prophase an

组织表达

Widely expressed.

储存（Storage）

-20°C/1 year

BYab-01040

产品简介>

宿主

反应性

应用

分子量（DA）

免疫原

特异性

来源

组成（Formulation）

稀释比例

纯化工艺（Immunogen）

浓度

背景（Background）

功能

基因名称（Gene Name）

蛋白名称

简称

其他名称

Fields

人基因ID

人蛋白质序列数据库

小鼠基因ID

小鼠蛋白质序列数据库

大鼠基因ID

大鼠蛋白质序列数据库

细胞定位

组织表达

储存（Storage）

实验方案>

引用文献(0)>

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hnRNP U Monoclonal Antibody

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