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SUZ12 Monoclonal Antibody

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BYab-01025

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  • 货期: 3天左右

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宿主
反应性
应用
WB;IF;ELISA
分子量(DA)
免疫原
Purified recombinant fragment of human SUZ12 expressed in E. Coli.
特异性
SUZ12 Monoclonal Antibody detects endogenous levels of SUZ12 protein.
来源
Monoclonal, Mouse
组成(Formulation)
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
稀释比例
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺(Immunogen)
Affinity purification
浓度
背景(Background)
This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009],
功能
caution:Two variants of the PRC2 complex have been described, termed PRC3 and PRC4. Each of the three complexes may include a different complement of EED isoforms, although the precise sequences of the isoforms in each complex have not been determined. The PRC2 and PRC4 complexes may also methylate 'Lys-26' of histone H1 in addition to 'Lys-27' of histone H3 (PubMed:15099518 and PubMed:15684044), although other studies have demonstrated no methylation of 'Lys-26' of histone H1 by PRC2 (PubMed:16431907).,developmental stage:Expressed at low levels in quiescent cells. Expression rises at the G1/S phase transition.,disease:A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors. Translocation t(7;17)(p15;q21) with JAZF1. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is freque
基因名称(Gene Name)
SUZ12
蛋白名称
Polycomb protein SUZ12
简称
SUZ12
其他名称
SUZ12; CHET9; JJAZ1; KIAA0160; Polycomb protein SUZ12; Chromatin precipitated E2F target 9 protein; ChET 9 protein; Joined to JAZF1 protein; Suppressor of zeste 12 protein homolog
Fields
人基因ID
23512
人蛋白质序列数据库
Q15022
小鼠基因ID
小鼠蛋白质序列数据库
Q80U70
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Nucleus . Localizes to chromatin as part of the PRC2 complex. .
组织表达
Overexpressed in breast and colon cancer.
储存(Storage)
-20°C/1 year

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SUZ12 Monoclonal Antibody

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