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SRA1 Monoclonal Antibody

说明书

BYab-01023

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB;IHC;IF;ELISA
分子量(DA)
免疫原
Purified recombinant fragment of SRA1 expressed in E. Coli.
特异性
SRA1 Monoclonal Antibody detects endogenous levels of SRA1 protein.
来源
Monoclonal, Mouse
组成(Formulation)
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/200 - 1/1000. ELISA: 1/10000.. IF 1:50-200
纯化工艺(Immunogen)
Affinity purification
浓度
背景(Background)
Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012],
功能
function:Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.,miscellaneous:Appears to be the first example of a new class of functional RNAs also able to encode a protein.,similarity:Belongs to the SRA1 family.,subunit:SRA1 RNA exists in a ribonucleoprotein complex containing NCOA1. The RNA also forms a complex with PUS1 and RARG in the nucleus. Interacts with AR.,tissue specificity:Highly expressed in liver and skeletal muscle and to a lesser extent in brain. Als
基因名称(Gene Name)
SRA1
蛋白名称
Steroid receptor RNA activator 1
简称
SRA1
其他名称
SRA1; PP7684; Steroid receptor RNA activator 1; Steroid receptor RNA activator protein; SRAP
Fields
人基因ID
10011
人蛋白质序列数据库
Q9HD15
小鼠基因ID
小鼠蛋白质序列数据库
Q80VJ2
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Nucleus . Cytoplasm .
组织表达
Highly expressed in liver and skeletal muscle and to a lesser extent in brain. Also expressed in both normal and tumorigenic breast epithelial cell lines. Significantly up-regulated in human tumors of the breast, ovary, and uterus.
储存(Storage)
-20°C/1 year

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SRA1 Monoclonal Antibody

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