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JMJD1A Monoclonal Antibody

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BYab-00995

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB;IF;ELISA
分子量(DA)
免疫原
Purified recombinant fragment of human JMJD1A expressed in E. Coli.
特异性
JMJD1A Monoclonal Antibody detects endogenous levels of JMJD1A protein.
来源
Monoclonal, Mouse
组成(Formulation)
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
稀释比例
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺(Immunogen)
Affinity purification
浓度
背景(Background)
This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009],
功能
cofactor:Binds 1 Fe(2+) ion per subunit.,domain:Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.,domain:The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.,function:Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1
基因名称(Gene Name)
KDM3A
蛋白名称
Lysine-specific demethylase 3A
简称
JMJD1A
其他名称
KDM3A; JHDM2A; JMJD1; JMJD1A; KIAA0742; TSGA; Lysine-specific demethylase 3A; JmjC domain-containing histone demethylation protein 2A; Jumonji domain-containing protein 1A
Fields
>>Thermogenesis
人基因ID
55818
人蛋白质序列数据库
Q9Y4C1
小鼠基因ID
小鼠蛋白质序列数据库
Q6PCM1
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Cytoplasm . Nucleus . Nuclear in round spermatids. When spermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in mature spermatozoa (By similarity). .
组织表达
Adrenal gland,Brain,Fetal kidney,Salivary gland,Testis,
储存(Storage)
-20°C/1 year

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JMJD1A Monoclonal Antibody

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