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Gfi-1 Monoclonal Antibody

说明书

BYab-00989

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB;ELISA
分子量(DA)
免疫原
Purified recombinant fragment of human Gfi-1 expressed in E. Coli.
特异性
Gfi-1 Monoclonal Antibody detects endogenous levels of Gfi-1 protein.
来源
Monoclonal, Mouse
组成(Formulation)
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺(Immunogen)
Affinity purification
浓度
背景(Background)
This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008],
功能
disease:Defects in GFI1 are a cause of autosomal dominant severe congenital neutropenia (SCN) [MIM:202700].,disease:Defects in GFI1 are a cause of dominant nonimmune chronic idiopathic neutropenia of adults (NI-CINA) [MIM:607847]. NI-CINA is a relatively mild form of neutropenia diagnosed in adults, but predisposing to leukemia in a subset of patients.,domain:The Gly/Ala-rich region may indicate that Gfi-1 is a repressor of its target genes.,function:May be a transcription factor involved in regulating the expression of genes active in the S phase during cell cycle progression in T-cells. May be involved in tumor progression (By similarity). Represses ELA2 transcription.,online information:GFI1 mutation db,similarity:Contains 6 C2H2-type zinc fingers.,subunit:Interacts with U2AF1L4.,
基因名称(Gene Name)
GFI1
蛋白名称
Zinc finger protein Gfi-1
简称
Gfi-1
其他名称
GFI1; ZNF163; Zinc finger protein Gfi-1; Growth factor independent protein 1; Zinc finger protein 163
Fields
人基因ID
2672
人蛋白质序列数据库
Q99684
小鼠基因ID
小鼠蛋白质序列数据库
P70338
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Nucleus . Colocalizes with PIAS3 and RUNX1T1 in nuclear dots.
组织表达
Bone marrow,Lung,Spleen,Testis,Thymus,
储存(Storage)
-20°C/1 year

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Gfi-1 Monoclonal Antibody

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