免疫原
The antiserum was produced against synthesized peptide derived from the C-terminal region of human APOC3. AA range:46-95
特异性
ApoC-III Polyclonal Antibody detects endogenous levels of ApoC-III protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008],
功能
disease:Defects in APOC3 may be a cause of hyperalphalipoproteinemia [MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).,function:Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.,PTM:O-linked glycan consists of Gal-GalNAc disaccharide, further modified with up to 3 sialic acid residues.,similarity:Belongs to the apolipoprotein C3 family.,tissue specificity:Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine.,
蛋白名称
Apolipoprotein C-III
其他名称
APOC3; Apolipoprotein C-III; Apo-CIII; ApoC-III; Apolipoprotein C3
Fields
>>PPAR signaling pathway;>>Cholesterol metabolism
联系我们
关注我们
您当前的位置： 
说明书
成功添加到购物车
