免疫原
The antiserum was produced against synthesized peptide derived from human ABCA8. AA range:1151-1200
特异性
ABCA8 Polyclonal Antibody detects endogenous levels of ABCA8 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The encoded protein may regulate lipid metabolism and be involved in the formation and maintenance of myelin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],
功能
function:ATP-dependent lipophilic drug transporter.,similarity:Belongs to the ABC transporter family. ABCA subfamily.,similarity:Contains 2 ABC transporter domains.,tissue specificity:Widely expressed with higher expression in heart, skeletal muscle and liver.,
蛋白名称
ATP-binding cassette sub-family A member 8
其他名称
ABCA8; KIAA0822; ATP-binding cassette sub-family A member 8
Fields
>>ABC transporters
细胞定位
Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane . Predominantly expressed on the sinusoidal plasma membrane. .
组织表达
Widely expressed with higher expression in heart, skeletal muscle and liver (PubMed:12379217, PubMed:28882873, PubMed:29300488). Highly expressed in the superior frontal white matter and inferior temporal white matter (PubMed:12379217).
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