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ApoA-IV Monoclonal Antibody

说明书

BYab-00598

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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产品简介>

宿主
反应性
应用
WB;ELISA
分子量(DA)
免疫原
Purified recombinant fragment of ApoA-IV (aa21-396) expressed in E. Coli.
特异性
ApoA-IV Monoclonal Antibody detects endogenous levels of ApoA-IV protein.
来源
Monoclonal, Mouse
组成(Formulation)
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺(Immunogen)
Affinity purification
浓度
背景(Background)
Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008],
功能
domain:Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities.,function:May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.,online information:The Singapore human mutation and polymorphism database,polymorphism:Eight alleles have been characterized (APOA-IV*0 to APOA-IV*7). APOA-IV*1 is the major allele (90%), APOA-IV*2 is also common (8%), the others are rare alleles.,similarity:Belongs to the apolipoprotein A1/A4/E family.,tissue
基因名称(Gene Name)
APOA4
蛋白名称
Apolipoprotein A-IV
简称
ApoA-IV
其他名称
APOA4; Apolipoprotein A-IV; Apo-AIV; ApoA-IV; Apolipoprotein A4
Fields
>>Fat digestion and absorption;>>Vitamin digestion and absorption;>>Cholesterol metabolism;>>Lipid and atherosclerosis
人基因ID
337
人蛋白质序列数据库
P06727
小鼠基因ID
小鼠蛋白质序列数据库
P06728
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Secreted.
组织表达
Synthesized primarily in the intestine and secreted in plasma.
储存(Storage)
-20°C/1 year

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ApoA-IV Monoclonal Antibody

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