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PAR4 Polyclonal Antibody

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BYab-00480

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB;IHC;IF;ELISA
分子量(DA)
36kD
免疫原
The antiserum was produced against synthesized peptide derived from human Prostate Apoptosis Response protein-4. AA range:291-340
特异性
PAR4 Polyclonal Antibody detects endogenous levels of PAR4 protein.
来源
Polyclonal, Rabbit,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
背景(Background)
The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. [provided by RefSeq, Jul 2008],
功能
domain:The leucine-zipper domain is not essential for apoptosis, but is required for sensitization of cells to exogenous apoptotic insults and for interaction with its partners.,domain:The SAC domain is a death-inducing domain selective for apoptosis induction in cancer cells. This domain is essential for nuclear entry, Fas activation, inhibition of NF-kappa-B activity and induction of apoptosis in cancer cells.,function:Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein
基因名称(Gene Name)
PAWR
蛋白名称
PRKC apoptosis WT1 regulator protein
简称
PAR4
其他名称
PAWR; PAR4; PRKC apoptosis WT1 regulator protein; Prostate apoptosis response 4 protein; Par-4
Fields
人基因ID
5074
人蛋白质序列数据库
Q96IZ0
小鼠基因ID
114774
小鼠蛋白质序列数据库
Q925B0
大鼠基因ID
64513
大鼠蛋白质序列数据库
Q62627
细胞定位
Cytoplasm. Nucleus. Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies. .
组织表达
Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers.
储存(Storage)
-20°C/1 year

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PAR4 Polyclonal Antibody

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