免疫原
The antiserum was produced against synthesized peptide derived from human OGFR. AA range:138-187
特异性
OGFR Polyclonal Antibody detects endogenous levels of OGFR protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. [provided by RefSeq, Jul 2008],
功能
function:Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation.,online information:OGFr entry,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the opioid growth factor receptor family.,subcellular location:The OGF/OGFR complex is probably translocated to the nucleus.,tissue specificity:Highly expressed in the heart and liver, moderately in skeletal muscle and kidney and to a lesser extent in brain and pancreas. Expressed in fetal tissues including liver and kidney.,
蛋白名称
Opioid growth factor receptor
其他名称
OGFR; Opioid growth factor receptor; OGFr; Protein 7-60; Zeta-type opioid receptor
细胞定位
Cytoplasm . Nucleus . The OGF/OGFR complex is probably translocated to the nucleus.
组织表达
Highly expressed in the heart and liver, moderately in skeletal muscle and kidney and to a lesser extent in brain and pancreas. Expressed in fetal tissues including liver and kidney.
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