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MSH2 Polyclonal Antibody

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BYab-00454

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
IHC;IF;ELISA
分子量(DA)
100kD
免疫原
The antiserum was produced against synthesized peptide derived from human MSH2. AA range:541-590
特异性
MSH2 Polyclonal Antibody detects endogenous levels of MSH2 protein.
来源
Polyclonal, Rabbit,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
背景(Background)
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012],
功能
disease:Defects in MSH2 are a cause of Muir-Torre syndrome (MTS) [MIM:158320]. MTS is a rare autosomal dominant disorder characterized by sebaceous neoplasms and visceral malignancy.,disease:Defects in MSH2 are a cause of susceptibility to endometrial cancer [MIM:608089].,disease:Defects in MSH2 are the cause of hereditary non-polyposis colorectal cancer type 1 (HNPCC1) [MIM:120435]. Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (CRC) and extra-colonic cancers of the gastrointestinal, urological and femal
基因名称(Gene Name)
MSH2
蛋白名称
DNA mismatch repair protein Msh2
简称
MSH2
其他名称
MSH2; DNA mismatch repair protein Msh2; hMSH2; MutS protein homolog 2
Fields
>>Platinum drug resistance;>>Mismatch repair;>>Pathways in cancer;>>Colorectal cancer
人基因ID
4436
人蛋白质序列数据库
P43246
小鼠基因ID
17685
小鼠蛋白质序列数据库
P43247
大鼠基因ID
81709
大鼠蛋白质序列数据库
P54275
细胞定位
Nucleus . Chromosome .
组织表达
Ubiquitously expressed.
储存(Storage)
-20°C/1 year

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MSH2 Polyclonal Antibody

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