免疫原
The antiserum was produced against synthesized peptide derived from human DLEC1. AA range:1-50
特异性
DLEC1 Polyclonal Antibody detects endogenous levels of DLEC1 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The cytogenetic location of this gene is 3p21.3, and it is located in a region that is commonly deleted in a variety of malignancies. Down-regulation of this gene has been observed in several human cancers including lung, esophageal, renal tumors, and head and neck squamous cell carcinoma. In some cases, reduced expression of this gene in tumor cells is a result of aberrant promoter methylation. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins.[provided by RefSeq, Mar 2016],
功能
alternative products:At least six differentially spliced products may exist,disease:Defects in DLEC1 may be a cause of breast cancer.,disease:Defects in DLEC1 may be a cause of esophageal cancer [MIM:133239].,disease:Defects in DLEC1 may be a cause of primary lung cancer [MIM:211980]. In 33% of lung, esophageal and renal cancer cell lines and primary cancers, there is a lack of functional transcripts and an increase in alternatively spliced non-functional transcripts; the gene itself is not altered.,disease:Defects in DLEC1 may be a cause of renal cancer.,function:May act as a tumor suppressor by inhibiting cell proliferation.,sequence caution:Intron retention.,tissue specificity:Expressed in all tissues examined. Expression is highest in prostate and testis.,
蛋白名称
Deleted in lung and esophageal cancer protein 1
其他名称
DLEC1; DLC1; Deleted in lung and esophageal cancer protein 1; Deleted in lung cancer protein 1; DLC-1
组织表达
Expressed in all tissues examined. Expression is highest in prostate and testis.
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